Would you please download and install the one-off patch for your database version and OS for bugs not included in RU yet? If you do not find a patch for your specific version and OS from MOS, please open a Service Request with details on the patch needed. In addition, please include a list of patches already applied (opatch lsinventory -detail) and any other patches you intend to apply.
Some of the Optimizer bug fixes (not all) are controlled by the “_FIX_CONTROL” setting and are DISABLED by default in 19c when installed either through one-off backport or through RUs. Please refer to the corresponding Patch Readme carefully for one-off patches and enable the fixed control to activate the fix.